High Estrogens in Women: What to Do?

Estrogen is a group of primary female sex hormones crucial for the normal development of secondary sex characteristics and the reproductive system.

In some cases, high estrogens in women may develop naturally — for example, during pregnancy, which may also decrease symptoms of some autoimmune diseases [1]. But elevated estrogen can also signal serious underlying conditions.

Main Reasons for High Estrogens in Women

Various health problems can cause elevated estrogen levels, including:

• Liver diseases
• Obesity
• Tumors of the female reproductive system

Certain medications can also raise estrogen levels:

• Some types of antibiotics [2]
• Phenothiazines
• Oral contraceptives
• Some natural and herbal remedies

These are not exhaustive — other causes exist, which is why a doctor’s consultation is essential before making any treatment decisions.

Primary Symptoms of High Estrogens in Women

Symptoms that may indicate elevated estrogen include:

• Decreased libido
• Anxiety
• Breast tenderness
• Irregular periods
• Highly expressed PMS
• Swelling
• Cognitive difficulties (brain fog, memory issues)
• Migraines — per a review in Post Reproductive Health, increased estrogen levels can trigger migraines in women [3]

How to Treat This Condition

Any significant change in hormonal background requires specialized medical evaluation. If you experience any of the above symptoms, a full endocrine system analysis is the appropriate first step.

When elevated estrogen is confirmed, possible treatments include:

• Aromatase inhibitors to reduce estrogen production
• Leuprolide or goserelin (GnRH analogs) in specific cases
• Surgical intervention if a tumor (such as an ovarian tumor) is the underlying cause

The appropriate treatment is determined by the root cause and should be individualized in consultation with your physician.

How to Monitor Estrogen Levels Properly

The best way to determine whether your estrogen level is within range is to use specific estrogen tests — which can measure estrogen levels in both urine and blood, depending on the test type and clinical need.

Since estrogens play a significantly important role in aging processes [4], monitoring their levels has become increasingly important in preventive medicine.

Note that urine and blood measurements are not interchangeable — your doctor will advise on the most appropriate test for your specific situation.